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Sunday 5 July 2009

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Nutritional status and function research programme (N05) - list of projects

Information about Agency-funded research projects investigating diet and bone health.

N05001: Evaluation of the effects of a 2-year intervention with calcium and vitamins D and K on bone health in elderly women

This research project aims to determine whether vitamin K alone, or in combination with vitamin D plus calcium, can reduce bone mineral loss in older women.

Results available.

N05011: Speciation, bioavailability, bio-potency, and functional markers for D vitamers

This research project aims to supplement data contained in national food tables about vitamin D, inform the assessment of dietary vitamin D intake on an 'at-risk' group of the population and provide a means of measuring vitamin D status in humans.

Results available.

N05018: The importance of meat consumption in regulating vitamin D metabolism and preventing metabolic bone disease

This research project aims to assess whether the consumption of meat provides protection against certain bone diseases and investigate vitamin D status and bone health in humans of different ethnic backgrounds.

Results available.

N05021: The extension and verification of the provisional UK phylloquinone (vitamin K1) food composition database

This research project aims to measure the amount of vitamin K1 in various foods in order to confirm and extend existing information.

Results available.

N05025: Optimal nutrition towards osteoporosis prevention - impact of diet and gene-nutrient interactions on calcium and bone metabolism

This research project aims to determine the effect of a high salt diet on the metabolism of calcium and bone in postmenopausal women and how it is influenced by the level of dietary calcium.

N05034: Interaction between silicon intake and vitamin D and K status on markers of bone health in older women

This research project aims to quantify the silicon intakes in older women, examine the relationship between silicon and bone health and examine possible interactions between silicon and other nutrients.

N05036: The interaction of vitamins K and D in bone and vascular health - new functional markers of vitamin K status

This research project aims to explore the optimal nutrition of vitamins K and D in elderly women.

N05043: Mechanisms by which fruit and vegetables influence postmenopausal bone health - a randomised control trial (RCT) in a well-characterised population

This research project aims to investigate how fruit and vegetables may improve postmenopausal bone health.

N05044: Impact of fruit and vegetables on bone health - potential mechanisms at whole body and cellular level

This research project aims to investigate the effects of fruit and vegetables on bone metabolism and bone mineral status in older adolescent boys and girls, young women and older men and women.

N05045: Are diets rich in vitamin A detrimental to bone health?

This research project aims to investigate the relationship between vitamin A intake and risk of bone fracture.

Results available.

N05046: Nutrition and bone health in men and women

This research project aims to examine the role of specific nutrients and foods in bone health.

N05049: The influence of diet in infancy on early growth, and bone health and cognitive function at four years of age

This research project aims to investigate the link between diet in early life and bone mass and cognitive function at 4 years.

N05062: 15 month longitudinal study of dietary and sunlight influences on vitamin D status in a well-characterized population of postmenopausal women at 57ºN

This research project aims to establish dietary vitamin D requirements for the UK. (Joint project with N05064).

N05063: Dietary requirements for vitamin D: An investigation of the relative significance of dietary intake and sunlight on vitamin D status in young and elderly adults

This research project will determine the total vitamin D intake needed to prevent seasonal vitamin D deficiency.

N05064: Interaction between diet and sunlight exposure on vitamin D status and functional markers of bone health in premenopausal and postmenopausal Caucasian and Asian women in Southern England.

This research project aims to determine the percentage contribution of (seasonal) diet and sunlight exposure on vitamin D statusor functional markers of calcium metabolism in Caucasian and Asian pre- and postmenopausal women. (Joint project with N05062)

N05076: The analysis of 25-hydroxy vitamin D to compare four different methods

N05079: Effect of 1 year vitamin D intervention on risk of cardiovascular disease: a randomized controlled trial at 57°N

N05081: Vitamin D status and associated health outcomes: towards an evidence basis for defining vitamin D status sufficient to reduce risk of chronic disease

Nutritional and genetic factors influencing perimenopausal bone loss - a longitudinal study in 3,800 British women (N05026)

This research project aims to explore the influence of nutrients on bone mineral density and recent bone loss around the time of the menopause, so that nutrients that help protect bone can be identified.

Results available.

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