Food Standards Agency
Saturday 4 July 2009
Safer food better business banner
AZ-Directory
What's NewRSS
What is RSS?Listen
Listen to this siteInformation about Agency-funded research projects
These interlinked research projects aimed to establish the role of heterocyclic amines in colorectal cancer and to determine whether particular genetic groups of the population are at a greater risk.
Results available.
This research project was a multidisciplinary collaboration combining development of biomarkers of DNA damage, biomarker use in human studies and research workshops.
Results available.
This research project aimed to establish an in vitro intestinal cell model for prediction of in vivo bioavailability of food components from the human diet.
Results available.
This research project investigates the effects of cruciferous vegetables upon the metabolism of potentially harmful genotoxins present in cooked meat.
Results available.
This research project investigates which drug-metabolising enzymes are present in human colon and whether expression is affected by cruciferous vegetable extracts.
Results available.
This research project aims to develop in vitro methodology for investigating the toxicological effects of dietary chemicals in liver and lung tissue.
Results available.
This research project examines the effects of heterocyclic amines and oxidative agents on the level of DNA adduct formation and repair in liver cells
Results available.
This research project describes the development and use of probabilistic models to look at patterns of food consumption and intakes of food chemicals.
Results available.
This research project aims to produce a statistical model which can estimate variability in dietary intake, between-person and within-person, whilst accounting for day-to-day variation.
Results available.
This research project seeks to develop biomarkers that are predictive of subsequent tumour formation by non-genotoxic chemicals.
Results available.
This research project aims to assess the DNA adducts, and the repair activities which modulate these levels, in the target cells.
Results available.
This research project aims to assess whether current default safety factors which are used in the risk assessment of food additives are sufficient to protect the consumer.
This research project seeks to develop a new model to address interactions between genotoxic and non-genotoxic food components of diets.
This research project aims to develop methods to assess the health effects from mixtures of food chemicals using four well characterised food additives.
This project investigates the influence of diet and genetic factors on susceptibility to colorectal adenomas and factors that predispose certain adenomas to become colorectal cancers.
This research project sought to determine whether 1,3-DCP and 2,3-DCP were genotoxic when tested using standard in vivo genotoxicity tests.
Results available.
This research project seeks to establish a strategy to identify molecular biomarkers of toxicity to assess early changes following exposure to potential neurotoxicants.
This research project aims to evaluate the potential toxicity of vitamin C supplements in a large number of human volunteers at high doses.
Results available.
This research project aims to develop urinary markers for estimation of in vivo production of glucosinolate hydrolysis products.
Results available.
This research project seeks to study the effects of vegetable storage, preparation and cooking, on glucosinolate and related metabolite content of Brassica vegetables.
Results available.
This project investigated, using the in vitro binucleate micronucleus assay, whether the concept of non-linear, threshold dose-response relationships can be applied to at least a proportion of the potentially mutagenic chemicals found in food.
This research project aims to investigate the relevance of elevated apparent total nitrosocompounds in the human colon, resulting from increased red meat consumption.
This research project proposes to determine the chemical nature of faecal ATNC together with its route of formation.
Results available.
This research project will address the issue of whether high maternal caffeine intake during pregnancy leads to an increased incidence of low birth weight babies.
This research project will address the issue of whether high maternal caffeine intake during pregnancy leads to an increased incidence of low birth weight babies.
This research project aims to refine the risk assessment of the human health effects of dioxins and dioxin-like PCBs ingested through the diet.
This research project investigates whether PhIP, or its metabolites, influence cell proliferation and cell growth.
Results available.
This research project aims to assess the levels of pyrrolizidine alkaloids in honey produced by bees living in hives close to areas where ragwort or borage are growing.
Results available.
This research project seeks to evaluate the genotoxicity of azo dyes and to investigate whether the genotoxicity occurs via a threshold mechanism
This research project aims to develop methods to assess the health effects from mixtures of food chemicals by using four well characterised food additives.
This research project aims to develop methods to assess the health effects from mixtures of food chemicals using four well characterised food additives.
This research project aims to develop a suite of quantitative methods for assessing and integrating beneficial and adverse effects of foods as web-based software.
This research project will investigate the effects of mixtures of food contaminants and additives with different modes of action.
This short research project aims to add to existing information on the reported anticancer effects of eating cruciferous vegetables using samples collected as part for a previous FSA project.
Find out what our other sites have to offer