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T05009: The use of 13 C isomers as analytical standards and as tracers of phytoestrogens in humans

Wednesday 22 October 2003

This research project aims to produce analytical standards for the accurate measurement of phytoestrogens in food.

Study Duration : December 1997 to May 2002

Contractor : MRC Dunn Human Nutrition Unit

Background

The ability to accurately measure phytoestrogens in food as well as in samples of blood and urine is vital to be able to assess human exposure to these compounds. However, such analysis is critically dependent on the availability of pure, chemically stable labelled analytical standards for phytoestrogens. However, the range and availability of these materials is limited. Therefore this project will develop methods for the preparation of analytical standards for phytoestrogens.

Research Approach

Labelled ( 13 C labels) phytoestrogens will be prepared by growing soya beans and linseed in 13 CO 2 -enriched air. The phytoestrogens produced by these plants will contain 13 C instead of 12 C. The labelled phytoestrogens will be extracted from the plants and purified for use in analytical studies.

Results and findings

This project developed methods for the preparation 13 C labelled analytical standards for phytoestrogens.

Key Results

Dissemination information

Final report is available from the FSA Library and Information centre. To obtain a copy, please contact the Enquiry Desk, Dr Elsie Widdowson Library and Information Services, Food Standards Agency tel: 020 7276 8181/8182 or email: library&info@foodstandards.gsi.gov.uk

Contact : Email : science@foodstandards.gsi.gov.uk

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