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Listen to this siteMonday 14 August 2006
This research project aims to investigate the effect of individual genetic responses to pesticides.
Study Duration : April 2006 to March 2008
Contractor : Newcastle University
In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) highlighted the need for characterisation of possible variability in human responses to mixtures of residues, including genetic susceptibility.
This project is designed to test whether genetic variability in sensitivity to neurotoxicity from pesticides may be due to variability in the delivery of toxins to the central nervous system (CNS) and variability in their distribution within the CNS.
To test this hypothesis, the specific aims of the project are to:
The outcome of this work will be a comprehensive understanding of the transport processes involved in the delivery of pesticides to the CNS, together with an explanation of the impact of SNPs of transporters upon CNS exposure to toxic substances and an understanding of the interactions between pesticides at the level in transporters that may modulate CNS exposure.
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