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Listen to this siteWednesday 6 July 2005
This research project aims to investigate potential interactions of mixtures of pesticides.
Study Duration : January 2005 to October 2007
Contractor : Health and Safety Laboratory
In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) recommended a need for investigation of the nature and dose-response relationships for combined actions of chemical mixtures.
This project focuses on possible combined actions of anticholinergic pesticides.
An in vitro model based on cholinesterase depression will be used to investigate the nature and dose-response relationships of anticholinergic carbamates and organophosphates that may be found in foodstuffs. These studies will determine whether effects are additive or otherwise. The effect of subsequent exposures will also be investigated. Should any significant interactions be observed, these will be investigated further in controlled human volunteer studies.
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