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Food Standards Agency

Saturday 4 July 2009

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Project details: Mixtures of pesticides research programme T10

Information about Agency-funded research projects.

T10002: Biomarkers of effect from exposure to mixtures of organophosphate pesticides

This research project aims to develop new ways of detecting systemic responses and health effects from exposure to organophosphate pesticides.

Results available.

T10003: Cost effective biomarkers of exposure to mixtures of pesticides – method development

This research project aims to develop cost effective biomarkers of mixed pesticide exposure.

Results available.

T10004: Use of protein profiles to characterise the concentration effects curve for mixtures of estrogenic compounds

This research project aims to investigate the effects of low concentrations of combinations of estrogenic chemicals.

T10005: Estimation of human uptake of pesticides and veterinary medicines from all potential exposure pathways

This research project will undertake a probabilistic assessment of the population uptake of pesticides and veterinary medicines from all potential exposure pathways.

Results available.

T10008: Dose-response and mixture response of pesticides in vitro and in vivo

This research project aims to investigate potential interactions of mixtures of pesticides.

T10009: Development of diagnostic immunoassays for biomarkers of pesticide exposure

This research project aims to develop assays for the detection of metabolites and bio-conjugates of several anticholinesterase pesticides.

T10010: Investigation of direct measurement of phosphorylation of the active site of esterases as sensitive biomarkers of organophosphate exposure

This research project will evaluate biomarkers at the low levels of pesticide residues to which consumers are exposed to in the diet.

T10011: Interindividuality in cytochrome P450 and paraoxonase mediated metabolism of mixtures of pesticides

This research project will investigate the influence of genetic variability in enzyme activity on the toxicity of mixtures of pesticides.

T10013: Development of cost-effective biomarkers for herbicides and fungicides

This project aims to develop cost-effective biomarkers of mixed pesticide exposure. The pesticides have been selected on the basis of their occurrence as residues in food.

T10014: A study to identify small metabolite biomarkers of effect following exposure to single or mixtures of pesticides

This research project aims to develop robust biomarkers to detect early pathological effects of low level pesticide residues in food.

T10015: Functional impact of polymorphisms of transport proteins upon pesticide delivery to the CNS

This research project aims to investigate the effect of individual genetic responses to pesticides.

T10016: Characterisation of the nature of combined actions of chemical mixtures and estimation of dose response relationships for pesticide mixtures

This research project aims to characterise potential interactions of mixtures of anti-acetylcholinesterase pesticides.

T10017: A pilot study to assess the effects of co-exposure to organophosphates, carbamates and pyrethroids on the rate of metabolic detoxification via hydrolysis

This research project aims to investigate the nature of the effects of combined exposure to pesticides on the major detoxification pathway.

Results available.

T10018: Pilot study into the chemical nature of organophosphate pesticide residues and the implications for urinary metabolite analysis

This research project is a pilot study that aims to investigate whether organophosphate degradation residues are found on foodstuffs.

T10019: The effects of storage time, preparation and cooking method on residual pesticide levels in apples and potatoes treated with a suite of commonly used permitted pesticides

This project aims to determine the effects of food preparation and cooking procedures on the persistence of a range of pesticides in UK apples and potatoes.

T10020: Application of protein profiles to identify common mechanism groups of pyrethrins and pyrethroids

This research project aims to identify groups of pyrethrins and pyrethroids sharing a common toxic effect by a common mechanism of action.

T10021: Immunoassay detection of urinary biomarkers of pesticide exposure

This project aims to develop immunodiagnostic tools for the detection of urinary metabolites of mixtures of pesticides and relevant veterinary residues to be used as indicators of what pesticides people have been exposed to.

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